932406-80-9Relevant articles and documents
Total synthesis of khafrefungin using highly stereoselective vinylogous Mukaiyama aldol reaction
Shirokawa, Shin-Ichi,Shinoyama, Mariko,Ooi, Isao,Hosokawa, Seijiro,Nakazaki, Atsuo,Kobayashi, Susumu
, p. 849 - 852 (2007/10/03)
(Chemical Equation Presented) A convergent total synthesis of khafrefungin was accomplished on the basis of (1) the highly stereoselective TiCl 4-mediated vinylogous Mukaiyama aldol reaction using vinylketene silyl N,O-acetal and (2) syn-select
Efficient total synthesis of khafrefungin: Convergent approach using Suzuki coupling under thallium-free conditions toward multigram-scale synthesis
Mori, Yuichiro,Nakamura, Masayuki,Wakabayashi, Takeshi,Mori, Kouhei,Kobayashi, Shu
, p. 601 - 603 (2007/10/03)
An efficient and practical synthetic route to khafrefungin, an antifungal agent, has been developed based on successive coupling of three components, 3, 4, and then 2. A key step of the synthesis is the Suzuki coupling of 2 and 10, in which the use of tox