932741-19-0 Usage
Description
2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine, also known as propargyl-PEG3-amine, is a PEG linker that is reactive with various functional groups such as carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde). The propargyl group in this compound allows for copper-catalyzed azide-alkyne click chemistry, making it a versatile building block for the synthesis of bioconjugates and drug delivery systems.
Uses
Used in Bioconjugation:
2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine is used as a PEG linker for bioconjugation, allowing for the attachment of various biomolecules, such as peptides, proteins, and nucleic acids, to other molecules or surfaces. The PEG spacer provides increased solubility, stability, and reduced immunogenicity to the conjugated biomolecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine is used as a building block for the development of drug delivery systems. The PEG linker can be used to attach drugs or other therapeutic agents to nanoparticles, liposomes, or other carriers, improving their solubility, stability, and bioavailability. The propargyl group allows for the incorporation of targeting ligands or imaging agents through click chemistry, enabling the development of targeted and stimuli-responsive drug delivery systems.
Used in Click Chemistry:
2-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)ethanamine is used as a reactant in copper-catalyzed azide-alkyne click chemistry, a powerful and versatile method for the rapid and efficient formation of new chemical bonds. This allows for the rapid assembly of complex molecules, materials, and bioconjugates, with potential applications in various fields, such as materials science, chemical biology, and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 932741-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,2,7,4 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 932741-19:
(8*9)+(7*3)+(6*2)+(5*7)+(4*4)+(3*1)+(2*1)+(1*9)=170
170 % 10 = 0
So 932741-19-0 is a valid CAS Registry Number.
932741-19-0Relevant articles and documents
A multimeric MRI contrast agent based on a: Closo -borane scaffold bearing modified AAZTA chelates on the periphery
Chakravarty, Shatadru,Sarma, Saurav J.,Goswami, Lalit N.,Cai, Quan-Yu,Shapiro, Erik M.,Hawthorne, M. Frederick,Ma, Lixin
, p. 12348 - 12351 (2019)
A multimeric MRI contrast agent based on the closo-borane motif is reported. Twelve copies of a modified AAZTA chelate with an alkyne end group are appended on an azide-functionalized closo-borane motif using Cu(i) catalyzed click chemistry. The presence of two water molecules on the Gd-bound AAZTA chelate results in high relaxivity for the closomer in vitro/in vivo.
A MedChem toolbox for cereblon-directed PROTACs
Steinebach, Christian,Sosi?, Izidor,Lindner, Stefanie,Bricelj, Ale?a,Kohl, Franziska,Ng, Yuen Lam Dora,Monschke, Marius,Wagner, Karl G.,Kr?nke, Jan,Gütschow, Michael
, p. 1037 - 1041 (2019/06/27)
A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.
AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME
-
, (2018/12/04)
Provided herein is the design and synthesis of novel molecular rotor fluorophores useful for detection of amyloid or amyloid like proteins. The fluorophores are designed to exhibit enhanced fluorescence emission upon associating with amyloid or amyloid like proteins as compared to unbound compound. Also disclosed herein are methods for treating diseases associated with amyloid or amyloid like proteins.
