93323-38-7Relevant articles and documents
Method for efficiently asymmetrically catalytically synthesizing pyrrole indoline
-
Paragraph 0055; 0056; 0057, (2018/03/28)
The invention discloses a method for efficiently asymmetrically catalytically synthesizing pyrrole indoline. According to the method, reaction is implemented on a compound 1 and a compound 2 as shown in the description by using chiral phosphoric acid as a catalyst, wherein R1 is selected from methyl and allyl, and R2 is selected from methyl and ethyl, or R1 and R2 equal to -(CH2)x-, and x is an integer from 2 to 6; R3 is an arbitrary substituent group, n is an integer from 1 to 4, and more than two R3 are the same or different when n is 2 or above; R4 is selected from CO2R and benzoyl, and R is alkyl; and R5 is an arbitrary substituent group, m is an integer from 1 to 4, and more than two R5 are the same or different when m is 2 or above. The synthesizing method is applicable to azobenzene derivatives of various esters, can be used for preparing the pyrrole indoline with excellent yield and excellent enantiomer selectivity, and the reacting condition is mild. The method provides a new way to organic catalytic asymmetric aryl functionalization.
Pd-catalyzed oxidative annulation of hydrazides with isocyanides: Synthesis of 2-amino-1,3,4-oxadiazoles
Fang, Tao,Tan, Qitao,Ding, Zhengwei,Liu, Bingxin,Xu, Bin
supporting information, p. 2342 - 2345 (2014/05/20)
An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4- oxadiazoles and their derivatives.
