933702-55-7Relevant articles and documents
Self-Replication and Amplification of Enantiomeric Excess of Chiral Multifunctionalized Large Molecules by Asymmetric Autocatalysis
Kawasaki, Tsuneomi,Nakaoda, Mai,Takahashi, Yutaro,Kanto, Yusuke,Kuruhara, Nanako,Hosoi, Kenji,Sato, Itaru,Matsumoto, Arimasa,Soai, Kenso
, p. 11199 - 11202 (2014)
Self-replication of large chiral molecular architectures is one of the great challenges and interests in synthetic, systems, and prebiotic chemistry. Described herein is a new chemical system in which large chiral multifunctionalized molecules possess asymmetric autocatalytic self-replicating and self-improving abilities, that is, improvement of their enantioenrichment in addition to the diastereomeric ratio. The large chiral multifunctionalized molecules catalyze the production of themselves with the same structure, including the chirality of newly formed asymmetric carbon atoms, in the reaction of the corresponding achiral aldehydes and reagent. The chirality of the large multifunctionalized molecules controlled the enantioselectivity of the reaction in a highly selective manner to construct multiple asymmetric stereogenic centers in a single reaction.
2 -Chloro -5-aldehyde pyrimidine and preparation method thereof
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Paragraph 0052-0071, (2019/07/04)
The invention discloses 2-chloro-5-aldehyde pyrimidine and a preparation method thereof. The preparation method comprises the following steps: step 1, adding Arnold salt into a solvent to obtain an arnold salt solution, the chemical structural formula of the Arnold salt is as shown in the specification (I); and step 2, adding chloroformamidine hydrochloride and an alkali into the Arnold salt solution to carry out ring-closing reaction so as to obtain the 2-chloro-5-aldehyde pyrimidine.
Preparation method of 2-chloro-5-aldehyde pyrimidine
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Paragraph 0059-0095, (2019/03/08)
The invention discloses a preparation method of 2-chloro-5-aldehyde pyrimidine. The preparation method includes the steps: a) performing hydrolysis reaction on 2-methoxyl-5-aldehyde pyrimidine servingas an initial raw material under acidic conditions to obtain 2-hydroxy-5-aldehyde pyrimidine, namely, a compound I; b) performing nucleophilic substitution reaction on the compound I and phosphorus oxychloride to obtain the 2-chloro-5-aldehyde pyrimidine, namely, a compound II. The preparation method is short in synthetic route, simple and convenient in operation, high in product yield and low insynthesis cost, raw materials are low in cost and easy to obtain, and industrial production requirements are met.