933770-71-9Relevant articles and documents
HETEROCYCLIC AMIDES AS ROCK INHIBITORS
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Page/Page column 81, (2011/10/03)
The present invention relates to new kinase inhibitors of formula (I), more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
Studies of ring-closing mode of 4-hydroxy-2-vinylidenebutanoates: 5-exo-trig versus 5-endo-dig
Kitagaki, Shinji,Shibata, Daisuke,Mukai, Chisato
, p. 1735 - 1738 (2008/02/05)
The ring-closing mode of benzyl 4-hydroxy-2-vinylidenebutanoates (5-exo-trig vs 5-endo-dig) could precisely be controlled in a highly selective manner by the proper choice of conditions (solvent and base).
Chemoenzymatic Approach to the Synthesis of the Antiviral Agents Penciclovir and Famciclovir in Isotopically Chiral Labelled Form
Sime, John T.,Barnes, Roger D.,Elson, Stephen W.,Jarvest, Richard L.,O'Toole, Kevin J.
, p. 1653 - 1658 (2007/10/02)
The antiviral agents penciclovir and famciclovir have been synthesised in isotopically chiral form.The synthesis of (+)-methyl 4-benzyloxy-2-(hydroxymethyl)butanoate 12a by use of enzymatic hydrolysis catalysed by the lipase from Candida cylindrac