934-34-9Relevant articles and documents
Influenza virus replication inhibitors and uses thereof
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Paragraph 0237; 0242-0244, (2021/07/01)
The invention belongs to the field of medicines, and particularly relates to novel compounds serving as an influenza virus replication inhibitor, a preparation method thereof, a pharmaceutical composition containing the compounds and application of the compounds and the pharmaceutical composition in treatment of influenza. The compounds are compounds as shown in a formula (I) or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or prodrugs of the stereoisomer, the tautomer, the nitrogen oxide, the solvate, the metabolite and the pharmaceutically acceptable salt of the compound as shown in the formula (I). The compounds not only can well inhibit influenza viruses, but also have lower cytotoxicity, excellent in-vivo pharmacokinetic property and the in-vivo pharmacodynamic property and good liver microsome stability.
Synthesis method of benzothiazolone compound
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Paragraph 0018-0026, (2021/11/03)
The invention discloses an economical and mild. The method adopts o-iodoaniline, elemental sulfur and DMF as raw materials, so that the yield of a target product of up to 3 hours can be obtained only 90%, and the synthesis strategy is compatible with a wide range of functional groups.
Method for preparing pesticide mefenacet from benzothiazolone and 2-halo-N-methyl-N-phenylacetamide
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Paragraph 0023-0025, (2020/07/13)
The invention provides a method for preparing mefenacet from benzothiazolone and 2-halo-N-methyl-N-phenylacetamide. The method comprises the following steps: firstly, synthesizing benzothiazolone by taking CO2 as a carbonylation reagent, then reacting the benzothiazolone with alkali liquor to obtain a salt solution of benzothiazolone, and finally reacting the salt solution of benzothiazolone with2-halo-N-methyl-N-phenylacetamide to obtain the mefenacet. A new path is provided for industrial production of mefenacet, the synthesis route of a traditional method is shortened, chemical utilizationof CO2 is achieved, energy conservation and emission reduction are facilitated, and the method better conforms to the concept of green chemistry.