93408-26-5Relevant articles and documents
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
Tarnchompoo, Bongkoch,Chitnumsub, Penchit,Jaruwat, Aritsara,Shaw, Philip J.,Vanichtanankul, Jarunee,Poen, Sinothai,Rattanajak, Roonglawan,Wongsombat, Chayaphat,Tonsomboon, Aunchalee,Decharuangsilp, Sasithorn,Anukunwithaya, Tosapol,Arwon, Uthai,Kamchonwongpaisan, Sumalee,Yuthavong, Yongyuth
, p. 1235 - 1240 (2018)
The S108N mutation of dihydrofolate reductase (DHFR) renders Plasmodium falciparum malaria parasites resistant to pyrimethamine through steric clash with the rigid side chain of the inhibitor. Inhibitors with flexible side chains can avoid this clash and
