934343-04-1

Basic information

• Product Name: 5-acetylamino-4-(biphenyl-2-ylmethoxy)-6-[(2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester
• CAS NO: 934343-04-1
• Molecular Weight: 511.572
• Mol File: 934343-04-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-acetylamino-4-(biphenyl-2-ylmethoxy)-6-[(2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-acetylamino-4-(biphenyl-2-ylmethoxy)-6-[(2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester(934343-04-1)
• EPA Substance Registry System: 5-acetylamino-4-(biphenyl-2-ylmethoxy)-6-[(2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester(934343-04-1)

Safety Data

• Hazardous Substances Data: 934343-04-1(Hazardous Substances Data)

Upstream product

• 25875-99-4 methyl 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonate 
• 67670-69-3 N-acetyl-4,7,8,9-tetra-O-acetyl-2-chloro-2-deoxyneuraminic acid methyl ester 
• 73960-72-2 methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate 

Relevant articles and documents

Synthesis and evaluation of 4-O-alkylated 2-deoxy-2,3-didehydro-N-acetylneuraminic acid derivatives as inhibitors of human parainfluenza virus type-3 sialidase activity

The X-ray crystal structure of the paramyxoviral surface glycoprotein haemagglutinin-neuraminidase (HN) from Newcastle Disease virus was used as a template to design inhibitors of the HN from human parainfluenza virus type-3 (hPIV-3). 4-O-Alkylated derivatives of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (Neu5Ac2en), accessed from 8,9-O-isopropylidenated-Neu5Ac2en1Me, were found to inhibit the sialidase (neuraminidase) activity of hPIV-3 (strain C243) in the range of 3-30 μM. This is comparable or improved activity compared to the parent 4-hydroxy compound.