93449-44-6Relevant articles and documents
Diaryl azo derivatives as anti-diabetic and antimicrobial agents: synthesis, in vitro, kinetic and docking studies
Tahir, Tehreem,Shahzad, Mirza Imran,Tabassum, Rukhsana,Rafiq, Muhammad,Ashfaq, Muhammad,Hassan, Mubashir,Kotwica-Mojzych, Katarzyna,Mojzych, Mariusz
, p. 1509 - 1520 (2021/07/16)
In the present study, a series of azo derivatives (TR-1 to TR-9) have been synthesised via the diazo-coupling approach between substituted aromatic amines with phenol or naphthol derivatives. The compounds were evaluated for their therapeutic applications against alpha-glucosidase (anti-diabetic) and pathogenic bacterial strains E. coli (gram-negative), S. aureus (gram-positive), S. aureus (gram-positive) drug-resistant strain, P. aeruginosa (gram-negative), P. aeruginosa (gram-negative) drug-resistant strain and P. vulgaris (gram-negative). The IC50 (μg/mL) of TR-1 was found to be most effective (15.70 ± 1.3 μg/mL) compared to the reference drug acarbose (21.59 ± 1.5 μg/mL), hence, it was further selected for the kinetic studies in order to illustrate the mechanism of inhibition. The enzyme inhibitory kinetics and mode of binding for the most active inhibitor (TR-1) was performed which showed that the compound is a non-competitive inhibitor and effectively inhibits the target enzyme by binding to its binuclear active site reversibly.
Tautomerisation in 1-(4-methylphenylazo)naphthalen-2-ol and 2-(4-methylphenylazo)-4-methylphenol: a crystallographic and NMR study.
Cross, Wendy I.,Flower, Kevin R.,Pritchard, Robin G.
, p. 834 - 853 (2007/10/03)
1-(4-methylphenylazo)naphthalen-2-ol 1 and 2-(4-methylphenylazo)-4-methylphenol 3 have been converted to their acetic acid esters 2 and 4 by treatment with NaH followed by acetyl chloride in good yield. Compounds 2, 3 and 4 have been structurally characte
