934562-64-8Relevant articles and documents
A new protecting group and linker for uridine ureido nitrogen
Wang, Yong,Kurosu, Michio
scheme or table, p. 4797 - 4804 (2012/08/08)
(2,6-Dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl) methoxymethyl chloride [1, monomethoxydiph-enylmethoxylmethyl chloroide (MDPM-Cl)] shows a significant relative stability and 1 reacts with uridine ureido nitrogen in the presence of DBU to form the corresponding protected uridine 8 in 95% yield. The MDPM-protected uridines are stable to a wide variety of conditions utilized for the synthesis of analogs of capuramycin and muraymycins. Significantly, the MDPM protecting group can conveniently be deprotected by using 30% TFA in CH 2Cl2. In addition, polymer-bound MDPM-Cl 23 is useful for immobilization of uridine derivatives.
Acid and base stable diphenylmethanol derivatives and methods of use
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Page/Page column 6; 15-16; 18-19, (2008/12/08)
The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.
High-throughput synthesis of substituted hydrazine derivatives
Kurosu, Michio,Narayanasamy, Prabagaran,Crick, Dean C.
scheme or table, p. 169 - 175 (2009/09/08)
Regioselective alkylations of the hydrazine derivatives are achieved by using the (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methoxycarboxyl resin. High-throughput synthesis of monosubstituted and 1,1-disubstituted hydrazine building blocks is desc