934986-87-5

Basic information

• Product Name: 1-(4-fluorophenyl)-4-methoxy-1H-indazole
• Synonyms: 1-(4-fluorophenyl)-4-methoxy-1H-indazole
• CAS NO: 934986-87-5
• Molecular Weight: 242.253
• Mol File: 934986-87-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)-4-methoxy-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)-4-methoxy-1H-indazole(934986-87-5)
• EPA Substance Registry System: 1-(4-fluorophenyl)-4-methoxy-1H-indazole(934986-87-5)

Safety Data

• Hazardous Substances Data: 934986-87-5(Hazardous Substances Data)

Upstream product

• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 146137-74-8 2-fluoro-6-methoxybenzaldehyde 
• 105728-90-3 2-fluoro-5-methoxybenzaldehyde 
• 371-14-2 4-fluorophenylhydrazine 

Downstream Products

• 934987-50-5 2-((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)-1H-isoindole-1,3(2H)-dione 
• 934987-51-6 ((1S)-2-{[1-(4-fluorophenyl)-1H-indazol-4-yl]oxy}-1-methylethyl)amine 
• 934986-88-6 1-(4-fluorophenyl)-1H-indazol-4-ol 

Relevant articles and documents

Discovery of indazole ethers as novel, potent, non-steroidal glucocorticoid receptor modulators

A structure-based design approach led to the identification of a novel class of indazole ether based, non-steroidal glucocorticoid receptor (GR) modulators. Several examples were identified that displayed cell potency in the picomolar range, inhibiting LPS-induced TNF-α release by primary peripheral blood mononuclear cells (PBMCs). Additionally, an improved steroid hormone receptor binding selectivity profile, compared to classical steroidal GR agonists, was demonstrated. The indazole ether core tolerated a broad range of substituents allowing for modulation of the physiochemical parameters. A small sub-set of indazole ethers, with pharmacokinetic properties suitable for oral administration, was investigated in a rat antigen-induced joint inflammation model and demonstrated excellent anti-inflammatory efficacy.

NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES

Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal).