93517-74-9

Basic information

• Product Name: 4-(3,4-dimethyl-phenyl)-2H-phthalazin-1-one
• Synonyms: 4-(3,4-dimethyl-phenyl)-2H-phthalazin-1-one
• CAS NO: 93517-74-9
• Molecular Weight: 250.3
• Mol File: 93517-74-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(3,4-dimethyl-phenyl)-2H-phthalazin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-dimethyl-phenyl)-2H-phthalazin-1-one(93517-74-9)
• EPA Substance Registry System: 4-(3,4-dimethyl-phenyl)-2H-phthalazin-1-one(93517-74-9)

Safety Data

• Hazardous Substances Data: 93517-74-9(Hazardous Substances Data)

Upstream product

• 95-47-6 o-xylene 
• 158529-52-3 3,4-dimethoxyphenylmethyleneaminophthalamide 
• 1875-48-5 N-aminophthalamide 
• 129934-45-8 3-(3,4-Dimethyl-phenyl)-3-hydroxy-2-phenyl-2,3-dihydro-isoindol-1-one 
• 2159-42-4 2-(3,4-dimethylbenzoyl)benzoic acid 

Downstream Products

• 1222411-01-9 [4-(3,4-dimethylphenyl)-1(2H)-oxophthalazin-2-yl]acetic acid ethyl ester 

Relevant articles and documents

POTASSIUM CHANNEL MODULATORS

Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring Z1, R1, p, R3, and R4 are as defined in the specification. Compositions comprising such compounds; and methods for treating conditions and disorders using such compounds and compositions are also described.

Synthesis and some reactions of 3,4-dimethoxyphenylmethyleneaminophthalimide

3,4-Dimethoxyphenylmethyleneaminophthalimide (1) reacts with aromatic hydrocarbons under Friedel-Craft's conditions to give 4-arylphthalazin-1-ones (2a-c).The reaction involves ring cleavage followed by cyclization and elimination of the aldehyde moiety.The investigation is extended to study the reaction of the title compound with Grignard reagents and amines leading to the formation of 2a, 4-6), respectively.

NEW CONVENIENT ONE-STEP SYNTHESIS OF 4-ARYLPHTHALAZ-1-ONES

4-Arylphthalaz-1-ones (2a-e) are prepared by the hitherto unknown reaction of N-aminophthalimide (1) with aromatic hydrocarbons under Friedel-Crafts conditions.The reaction of N-aminophthalimide with Grignard reagents presents another convenient method for the synthesis of 4-alkyl or 4-arylphthalaz-1-ones.