935468-53-4

Basic information

• Product Name: (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione
• Synonyms: (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione
• CAS NO: 935468-53-4
• Molecular Weight: 412.488
• Mol File: 935468-53-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione(935468-53-4)
• EPA Substance Registry System: (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-hydroxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione(935468-53-4)

Safety Data

• Hazardous Substances Data: 935468-53-4(Hazardous Substances Data)

Upstream product

• 1631-26-1 1-benzyl-1H-pyrrole-2,5-dione 
• 66-99-9 β-naphthaldehyde 
• 618-27-9 hydroxy L-proline 

Downstream Products

• 935468-94-3 (-)-(3aR,4S,7S,8aR,8bS)-7-fluorohexahydro-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione 
• 935468-92-1 (-)-S-methyl O-[(3aR,4S,7R,8aR,8bS)-decahydro-4-(naphthalen-2-yl)-1,3-dioxo-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizin-7-yl] dithiocarbonate 
• 935468-95-4 (-)-(3aR,4S,7R,8aR,8bS)-hexahydro-7-methoxy-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione 
• 935469-04-8 (-)-[(1S,2R,3S,6R,7aR)-hexahydro-6-methoxy-3-(naphthalen-2-yl)-2-{[(phenylmethyl)amino]carbonyl}-1H-pyrrolizin-1-yl]methyl bis(phenylmethyl) phosphate 
• 935469-03-7 (-)-((1S,2R,3S,6S,7aR)-6-fluorohexahydro-3-(naphthalen-2-yl)-2-{[(phenylmethyl)amino]carbonyl}-1H-pyrrolizin-1-yl)methyl bis(phenylmethyl) phosphate 
• 935469-02-6 (-)-[(1S,2R,3S,7aR)-hexahydro-3-(naphthalen-2-yl)-2-{[(phenylmethyl)amino]carbonyl}-1H-pyrrolizin-1-yl]methyl bis(phenylmethyl) phosphate 
• 935469-01-5 (-)-(1S,2R,3S,6R,7aR)-hexahydro-1-(hydroxymethyl)-6-methoxy-3-(naphthalen-2-yl)-N-(phenylmethyl)-1H-pyrrolizine-2-carboxamide 
• 935469-00-4 (-)-(1S,2R,3S,6S,7aR)-6-fluorohexahydro-1-(hydroxymethyl)-3-(naphthalen-2-yl)-N-(phenylmethyl)-1H-pyrrolizine-2-carboxamide 
• 935468-99-8 (-)-(1S,2R,3S,7aR)-hexahydro-1-(hydroxymethyl)-3-(naphthalen-2-yl)-N-(phenylmethyl)-1H-pyrrolizine-2-carboxamide 
• 935468-97-6 (-)-methyl (1S,2R,3S,6S,7aR)-6-fluorohexahydro-3-(naphthalen-2-yl)-2-{[(phenylmethyl)amino]carbonyl}-1H-pyrrolizine-1-carboxylate 
• 935468-96-5 (-)-methyl (1S,2R,3S,7aR)-hexahydro-3-(naphthalen-2-yl)-2-{[(phenylmethyl)amino]carbonyl}-1H-pyrrolizine-1-carboxylate 
• 935468-93-2 (-)-(3aR,4S,8aR,8bS)-hexahydro-4-(naphthalen-2-yl)-2-(phenylmethyl)pyrrolo[3,4-a]pyrrolizine-1,3(2H,4H)-dione 

Relevant articles and documents

A novel synthesis of highly substituted perhydropyrrolizines, perhydroindolizines, and pyrrolidines: Inhibition of the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1

In this paper, we describe the synthesis and biological evaluation of highly substituted perhydropyrrolizines that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1, an oncogenic target. The enzyme selectively catalyzes the cis/trans isomeriza