935764-13-9Relevant articles and documents
Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides
Nagaki, Aiichiro,Takahashi, Yusuke,Yoshida, Jun-Ichi
, p. 5327 - 5331 (2016/04/26)
Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. Go with the flow: Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used to react with electrophiles to give various amides, including α-ketoamides. The method was applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. PMB=p-methoxybenzyl; FG=functional group.
HETEROCYCLYL COMPOUNDS AS MEK INHIBITORS
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, (2013/09/26)
The present disclosure is related to heteroaryl compounds as MEK inhibitors. These compounds include heteroaryl compounds of Formula (I), their pharmaceutically acceptable salts, combinations with suitable medicament and pharmaceutical compositions thereo
