935861-30-6

Basic information

• Product Name: 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid
• Synonyms: 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid;2-(3-Ethoxyphenyl)-isonicotinic acid;2-(3-Trifluoromethoxyphenyl)-isonicotinic acid;2-(4-Ethoxyphenyl)-isonicotinic acid;2-(4-Methoxyphenyl)-isonicotinic acid;2-(4-Methylthiophenyl)-isonicotinic acid;2-(4-Trifluoromethoxyphenyl)-isonicotinic acid;5-(3-Ethoxyphenyl)-nicotinic acid
• CAS NO: 935861-30-6
• Molecular Formula: C₁₃H₁₁NO₃
• Molecular Weight: 229.23
• Mol File: 935861-30-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid(935861-30-6)
• EPA Substance Registry System: 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid(935861-30-6)

Safety Data

• Hazardous Substances Data: 935861-30-6(Hazardous Substances Data)

Usage

Derivative of isonicotinic acid

It is a modified version of the isonicotinic acid molecule, which is a heterocyclic aromatic organic compound.

Trifluoromethoxy group

The presence of a trifluoromethoxy group (-OCH3) on the phenyl ring gives the compound unique properties and reactivity.

Potential applications in medicinal chemistry

The compound has possible uses in the development of pharmaceutical drugs due to its unique structure and properties.

Synthesis of bioactive compounds

2-(2-Trifluoromethoxyphenyl)-isonicotinic acid can be used as a building block for creating other compounds with biological activity.

Targeting specific biological pathways

The compound may be useful in developing drugs that specifically interact with certain biological processes or pathways in the body.

Need for further research

More studies are needed to fully explore the potential applications and uses of 2-(2-Trifluoromethoxyphenyl)-isonicotinic acid in various fields.

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Relevant articles and documents

Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile

Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its ability to form spores, which are not susceptible to antibiotics. To address the urgent need for treating recurrent C. difficile infection, antibiotics that selectively target C. difficile over common gut microbiota are needed. We herein describe the class of picolinamide antibacterials which show potent and selective activity against C. difficile. The structure-activity relationship of 108 analogues of isonicotinamide 4, a compound that is equally active against methicillin-resistant Staphylococcus aureus and C. difficile, was investigated. Introduction of the picolinamide core as exemplified by analogue 87 resulted in exquisite potency and selectivity against C. difficile. The ability of the picolinamide class to selectively target C. difficile and to prevent gut dysbiosis holds promise for the treatment of recurrent C. difficile infection.