93595-52-9

Basic information

• Product Name: 1,3,4-Oxadiazol-2(3H)-one, 5-(2-amino-5-chlorophenyl)-
• CAS NO: 93595-52-9
• Molecular Formula: C8H6ClN3O2
• Molecular Weight: 211.608
• Mol File: 93595-52-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3,4-Oxadiazol-2(3H)-one, 5-(2-amino-5-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-Oxadiazol-2(3H)-one, 5-(2-amino-5-chlorophenyl)-(93595-52-9)
• EPA Substance Registry System: 1,3,4-Oxadiazol-2(3H)-one, 5-(2-amino-5-chlorophenyl)-(93595-52-9)

Safety Data

• Hazardous Substances Data: 93595-52-9(Hazardous Substances Data)

Upstream product

• 5584-15-6 5-chloroanthranilic acid hydrazide 
• 530-62-1 1,1'-carbonyldiimidazole 
• 183244-16-8 5-chloro-2-nitrobenzohydrazide 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 4743-17-3 5-Chloroisatoic anhydride 
• 635-21-2 5-chloroanthranilic acid 
• 5202-89-1 4-chlorobenzenesulfonyl chloride 
• 93595-34-7 1-(2-amino-5-chlorobenzoyl)-4,4-diphenylsemicarbazide 
• 344757-56-8 C₁₂H₁₇ClN₄O₂ 
• 344442-67-7 1-(2-amino-5-chlorobenzoyl)-4,4-dimethylsemicarbazide 

Relevant articles and documents

ARYLCARBOXAMIDES AND USES THEREOF

The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic diseases such as scleroderma; lung disease, such as pulmonary fibrosis including idiopathic pulmonary fibrosis (IPF); heart disease, such as heart failure due to ischaemic heart disease, valvular heart disease and hypertensive heart disease, diabetic cardiomyopathy and hypertension; liver disease, such as cirrhosis of the liver; and kidney disease, such as progressive kidney disease glomerulonephritis and diabetic nephropathy; and eye disease such as diabetic retinopathy; skin or subcutaneous scarring, such as keloids, adhesions, hypertrophic scarring or cosmetic scarring; or as an adjuvant or anti-fibrotic in pancreatic cancer to increase chemotherapeutic drug penetration by reducing the density of the connective tissue stroma.

The Preparation of 5-(2-Aminophenyl)-1,3,4-oxadiazole-2(3H)-one and Its Rearrangement to 3-Amino-2,4(1H,3H)-quinazolinedione

When anthranilic acid hydrazide is reacted with 1,1'-carbonyldiimidazole in THF 5-(2-aminophenyl)-1,3,4-oxadiazole-2(3H)-one (4) is formed.It can also be prepared from 1-o-aminobenzoyl-4,4-dimethylsemicarbazide which eliminates methylamine when boiled with DMF.On heating the 5-(2-aminophenyl)-1,3,4-oxadiazole above its melting point it rearranges to 3-amino-2,4(1H,3H)-quinazolinedione (5). - Keywords: 3,4-Dihydro-1H-1,3,4-benzotriazepine-2,5-dione; Oxadiazoles