936092-73-8

Basic information

• Product Name: 2-Chloro-N-(4-fluoro-3-methoxyphenyl)-5-methylpyrimidin-4-amine
• Synonyms: 2-Chloro-N-(4-fluoro-3-methoxyphenyl)-5-methylpyrimidin-4-amine
• CAS NO: 936092-73-8
• Molecular Formula: C12H11ClFN3O
• Molecular Weight: 267.69
• Mol File: 936092-73-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 426.9±45.0 °C (760 mmHg)
• Density: 1.349±0.06 g/cm3 (20 °C, 760 mmHg)
• CAS DataBase Reference: 2-Chloro-N-(4-fluoro-3-methoxyphenyl)-5-methylpyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-N-(4-fluoro-3-methoxyphenyl)-5-methylpyrimidin-4-amine(936092-73-8)
• EPA Substance Registry System: 2-Chloro-N-(4-fluoro-3-methoxyphenyl)-5-methylpyrimidin-4-amine(936092-73-8)

Safety Data

• Hazardous Substances Data: 936092-73-8(Hazardous Substances Data)

Upstream product

• 14394-70-8 2-chloro-4-amino-5-methylpyrimidine 
• 103291-07-2 4-bromo-1-fluoro-2-methoxy-benzene 

Relevant articles and documents

Synthesis and biological evaluation of novel 2,4-dianilinopyrimidine derivatives as potent dual janus kinase 2 and histone deacetylases inhibitors

Dual or multiple-targeting inhibition of oncogenic targets in a single molecule could be an alternative approach to drug combinations. Previous studies have revealed that histone deacetylases (HDAC) inhibitor in combination with janus kinase (JAK) inhibitor could exhibit synergistically anti-proliferative effects in cancer treatment. Herein, we presented a novel series of 2,4-dianilinopyrimidine derivatives, which could simultaneously inhibit JAK2 and HDAC1. Among which, 7l was found to be the most potent compound and displayed balanced inhibitory activity against HDAC1 (IC50 = 1.9 nM) and JAK2 (IC50 = 0.5 nM), respectively. 7l also demonstrated good antiproliferative activity against tested cancer cell lines (A549, HepG-2, MDA-MB-231 and Jurkat). Moreover, flow cytometric analysis showed that 7l induced apoptosis and cell cycle arrest in a dose-dependent manner, and the insight into mechanisms of 7l indicated that it could decrease the phosphorylation of STAT-3 and promote histone acetylation. In conclusion, these results together suggested that 7l would be a promising lead candidate and deserved further research and development.