936116-88-0

Basic information

• Product Name: 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester
• Synonyms: 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester
• CAS NO: 936116-88-0
• Molecular Weight: 948.129
• Mol File: 936116-88-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester(936116-88-0)
• EPA Substance Registry System: 2-[2-(2-{2-[2-(2-tert-butoxycarbonylamino-pent-4-enoylamino)-propionylamino]-pent-4-enoylamino}-pent-4-enoylamino)-3-(trityl-carbamoyl)-propionylamino]-pent-4-enoic acid methyl ester(936116-88-0)

Safety Data

• Hazardous Substances Data: 936116-88-0(Hazardous Substances Data)

Upstream product

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 132388-59-1 L-Asn(Trt) 
• 146549-21-5 2-(9H-fluoren-9-ylmethoxycarbonylamino)-pent-4-enoic acid 
• 170899-08-8 N-(tert-butoxycarbonyl)-D-allylglycine 
• 170642-28-1 (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pent-4-enoic acid 

Relevant articles and documents

Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic

Herein, we describe the synthesis, structural characterization, and synthetic use as an advanced intermediate of a cross-stapled alkene-bridged hexapeptide to mimic the DE-ring of the lantibiotic nisin. The linear precursor was cyclized by ring-closing metathesis to give the correctly folded bicyclic hexapeptide in a single step, and the four individual diastereoisomers were isolated, structurally assigned and characterized by HPLC, NMR and MS, respectively. The bicyclic hexapeptide was used as a versatile advanced synthon and was modified at its C- and N-terminus, among others, with an azide moiety to access a building block suitable for Cu(i)-catalyzed alkyne-azide cycloaddition-based ligation reactions.