936368-52-4Relevant articles and documents
Transition Metal-Free Approach to Propynenitriles and 3-Chloropropenenitriles
Sharma, Pawan K.,Ram, Sita,Chandak, Navneet
, p. 894 - 899 (2016)
A transition metal-free, facile and efficient one-pot protocol for the synthesis of propynenitriles from readily available 3-chloropropenals is disclosed. The reaction conditions have also been optimized for the exclusive formation and isolation of 3-chloropropenenitriles which are important building blocks in general and are intermediates in the synthesis of propynenitriles. The hallmark of the methodology is the use of non-toxic reagents, milder, metal-free and economically benign reaction conditions avoiding a harsh dehydration step while achieving excellent yields.
3-halo-3-aryl acrylonitrile and preparation method thereof
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Paragraph 0029; 0047-0049, (2018/05/16)
The invention discloses 3-halo-3-aryl acrylonitrile and a preparation method thereof. The method comprises the following steps: dissolving alkyne nitrile into a first substance comprising acetic acid,and adding alkaline metal halide salt to obtain a react
Synthesis and biological evaluation of 2-(3′,4′,5′- trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors
Romagnoli, Romeo,Baraldi, Pier Giovanni,Remusat, Vincent,Carrion, Maria Dora,Lopez Cara, Carlota,Preti, Delia,Fruttarolo, Francesca,Pavani, Maria Giovanna,Aghazadeh Tabrizi, Mojgan,Tolomeo, Manlio,Grimaudo, Stefania,Balzarini, Jan,Jordan, Mary Ann,Hamel, Ernest
, p. 6425 - 6428 (2007/10/03)
2-(3′,4′,5′-Trimethoxybenzoyl)-3-amino-5-aryl/heteroaryl thiophene derivatives were synthesized and evaluated for antiproliferative activity, inhibition of tubulin polymerization, and cell cycle effects. SARs were elucidated with various substitutions on
