936707-00-5Relevant articles and documents
The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH2 in antibacterial activity
Yan, Xuxu,Gao, Feng,Yotphan, Sirilata,Bakirtzian, Parseh,Auclair, Karine
, p. 2944 - 2951 (2008/02/01)
Aminoglycoside antibiotics act by binding to 16S rRNA. Resistance to these antibiotics occurs via drug modifications by enzymes such as aminoglycoside 6′-N-acetyltransferases (AAC(6′)s). We report here the regioselective and efficient synthesis of N-6′-ac