93673-09-7

Basic information

• Product Name: 1-Octanone, 1-[4-(2-methylpropyl)phenyl]-
• CAS NO: 93673-09-7
• Molecular Formula: C18H28O
• Molecular Weight: 260.42
• Mol File: 93673-09-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Octanone, 1-[4-(2-methylpropyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Octanone, 1-[4-(2-methylpropyl)phenyl]-(93673-09-7)
• EPA Substance Registry System: 1-Octanone, 1-[4-(2-methylpropyl)phenyl]-(93673-09-7)

Safety Data

• Hazardous Substances Data: 93673-09-7(Hazardous Substances Data)

Upstream product

• 538-93-2 1-phenyl-2-methylpropane 
• 111-64-8 n-octanoic acid chloride 

Downstream Products

• 148367-06-0 1-(4-Isobutylphenyl)octan-1-ol 
• 93673-08-6 1-Isobutyl-4-(1'-methyoctyl)benzene 
• 51146-57-7 (R)-ibuprofene 
• 51146-56-6 (S)-ibuprofen 
• 148366-64-7 Ethyl 4-[3-[4-[1-(4-isobutylphenyl)octyloxy]benzoyl]indol-1-yl]butyrate 
• 148367-10-6 1-(1-Bromooctyl)-4-isobutylbenzene 
• 93673-10-0 2-(4'-Isobutylphenyl)nonan-2-ol 

Relevant articles and documents

4-(Benzoylindolizinyl)butyric acids; novel nonsteroidal inhibitors of steroid 5α-reductase. III

A novel series of indolizinebutyric acids with various benzoyl substituents was synthesized to develop nonsteroidal inhibitors of steroid 5α-reductase, and the structure-activity relationships in this series were studied. We previously reported the structure-activity relationships in a series of indolebutyric acids as well as the discovery of the novel nonsteroidal 5α-reductase inhibitor, FK143. We have now made other modifications to this compound to improve in vivo inhibitory activity. By altering the heterocyclic nucleus and changing the benzoyl substituent we have succeeded in identifying the strongly active compound, FK687, (S)-4-[1-[4-[[1-(4-isobutylphenyl)butyl]oxy]benzoyl]indolizin-3-yllbutyric acid, which displays strong in vitro inhibitory activity against the human enzyme and in vivo inhibitory activity against the castrated young rat model. This compound should be a useful agent for the treatment of benign prostatic hyperplasia.

Preparation of (R)-Ibuprofen and Related Carboxylic Acids Using Microbial Oxidation of an Aromatic Hydrocarbon by Rhodococcus sp. BPM 1613

(R)-2-(4'-Isobutylphenyl)propanoic acid (ibuprofen), (S)-3-(4'-isobutylphenyl)butanoic acid and (S)-4-(4'-isobutylphenyl)pentanoic acid were obtained using microbial oxidation of (+)-1-isobutyl-4-(1'-methyloctyl)benzene by Rhodococcus sp.BPM 1613.