936845-71-5

Basic information

• Product Name: 4-PyriMidinaMine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-Methyl-6-(1-piperazinyl)-
• Synonyms: 4-PyriMidinaMine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-Methyl-6-(1-piperazinyl)-;TG101477;(E)-5-(2-(7-Chloro-1H-indol-4-yl)vinyl)-N-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)thiazol-2-amine
• CAS NO: 936845-71-5
• Molecular Formula: C22H22ClN7S
• Molecular Weight: 451.97498
• Mol File: 936845-71-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 717.9±70.0 °C(Predicted)
• Appearance: /
• Density: 1.426±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 15.17±0.30(Predicted)
• CAS DataBase Reference: 4-PyriMidinaMine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-Methyl-6-(1-piperazinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyriMidinaMine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-Methyl-6-(1-piperazinyl)-(936845-71-5)
• EPA Substance Registry System: 4-PyriMidinaMine, N-[5-[(1E)-2-(7-chloro-1H-indol-4-yl)ethenyl]-2-thiazolyl]-2-Methyl-6-(1-piperazinyl)-(936845-71-5)

Safety Data

• Hazardous Substances Data: 936845-71-5(Hazardous Substances Data)

Relevant articles and documents

THIAZOLE INHIBITORS TARGETING RESISTANT AND KINASE MUTATIONS

A compound is provided, having the general structure (A): wherein A is an aryl or heteroaryl group, Y is a hydrophobic linking moiety, and L is a substitutent. The compound (A) can be used for treatment of various angiogenic-associated or hematologic disorders, such as myeloproliferative disorders in patients who do not respond to kinase-inhibition therapy that comprises administering currently used medications.