936920-45-5Relevant articles and documents
Nonpeptide integrin antagonists: RGD mimetics incorporating substituted azabicycloalkanes as amino acid replacements
Manzoni, Leonardo,Bassanini, Michele,Belvisi, Laura,Motto, Ilaria,Scolastico, Carlo,Castorina, Massimo,Pisano, Claudio
, p. 1309 - 1317 (2008/09/18)
Azabicyclo[4.3.0]alkanes appropriately substituted on both cycles have been synthesized as potential scaffold mimics of the RGD signaling motif of integrin. Two sets of functionalized azabicycloalkanes have been examined. In vitro assays established that