93713-34-9Relevant articles and documents
ASYMMETRIC ALKYLATION OF CARBOXYAMIDES BY USING trans-2,5-DISUBSTITUTED PYRROLIDINES AS CHIRAL AUXILIARIES
Kawanami, Yasuhiro,Ito, Yoshio,Kitagawa, Toshiyuki,Taniguchi, Yoshiyuki,Katsuki, Tsutomu,Yamaguchi, Masaru
, p. 857 - 860 (2007/10/02)
trans-2,5-Bis(methoxymethyl)- and trans-2,5-bis(methoxymethoxymethyl)pyrrolidines proved to be excellent chiral auxiliaries for the asymmetric alkylation of the corresponding carboxyamide enolates giving good chemical yield and high stereoselectivity (invariably over 95percent de), with remarkable flexibility to substrates and reaction conditions.