937168-00-8Relevant articles and documents
Cascade synthesis of polyoxygenated 6H,11H-[2]benzopyrano-[4,3-c][1] benzopyran-11-ones
Naumov, Mikael I.,Sutirin, Sergey A.,Shavyrin, Andrey S.,Ganina, Olga G.,Beletskaya, Irina P.,Bourgarel-Rey, Veronique,Combes, Sebastien,Finet, Jean-Pierre,Fedorov, Alexey Yu.
, p. 3293 - 3301 (2008/02/03)
(Chemical Equation Presented) 2-(Methoxymethoxymethyl)aryllead triacetates, obtained in situ from the corresponding arylboronic acids, reacted with 4-hydroxycoumarins, leading to 3-(2-methoxymethoxymethyl)aryl-4-hydroxycoumarin derivatives in good to high yields. These compounds underwent a cascade sequence of reactions, deprotection-halogenation-annulation, to afford polyoxygenated tetracyclic 6H, 11H-[2]benzopyrano-[4,3-c] [1]benzopyran-11-ones in good yields. Some compounds showed a moderate cytotoxicity against human epithelial mammary HBL100 cells.