937248-77-6

Basic information

• Product Name: (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate
• Synonyms: (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate
• CAS NO: 937248-77-6
• Molecular Weight: 549.716
• Mol File: 937248-77-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate(937248-77-6)
• EPA Substance Registry System: (R)-tert-butyl 1-(4-(4-ethylbenzyl)-5-phenylethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethylcarbamate(937248-77-6)

Safety Data

• Hazardous Substances Data: 937248-77-6(Hazardous Substances Data)

Upstream product

• 937247-96-6 (R)-tert-butyl 1-(4-ethylbenzylamino)-3-(1H-indol-3-yl)-1-thioxopropan-2-ylcarbamate 
• 3538-68-9 3-phenylpropanehydrazide 
• 956489-60-4 (R)-tert-butyl 1-(4-ethylbenzylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamate 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 7441-43-2 4-ethylbenzylamine 
• 5241-64-5 Boc-D-Trp-OH 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 1027277-31-1 C₃₈H₄₆N₆O₃ 

Relevant articles and documents

New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations

Ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure were synthesized and evaluated for their in vitro binding and biological activity. In this study, we explored the replacement of the α- aminoisobutyryl moiety by aromatic or heteroaromatic groups. Compounds 5 and 34 acted as potent in vivo antagonists of hexarelin-stimulated food intake. These two compounds did not stimulate growth hormone secretion in rodents and did not antagonize growth hormone secretion induced by hexarelin.

Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations

A series of ghrelin receptor ligands based on the trisubstituted 1,2,4-triazole structure were synthesized and evaluated for their in vitro binding and biological activity. In this study, we explored the significance of the aminoisobutyryl (Aib) moiety, a common feature in numerous growth hormone secretagogues described in the literature. Potent agonist and antagonist ligands of the growth hormone secretagogue receptor type 1a (GHS-R1a) were obtained, i.e., compounds 41 (JMV2894) and 17 (JMV3031). The best compounds were evaluated for their in vivo activity on food intake, after sc injection in rodents. Among the tested compounds, few of them were able to stimulate food intake and some others, i.e., compounds 4 (JMV2959), 17, and 52 (JMV3021), acted as potent in vivo antagonist of hexarelin-stimulated food intake. These compounds did not stimulate growth hormone secretion in rats and furthermore did not antagonize growth hormone secretion induced by hexarelin, revealing that it is possible to modulate food intake without altering growth hormone secretion.