937602-40-9 Usage
Description
Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride is a chemical compound characterized by a molecular structure that features a pyrimidine ring fused to a pyrazole ring, with a carbonyl chloride functional group attached at the 3-position of the pyrimidine ring. Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride is recognized for its reactivity and potential applications in various fields.
Uses
Used in Organic Synthesis:
Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride is utilized as a reagent in organic synthesis, specifically for the preparation of pyrazolo[1,5-a]pyrimidine derivatives and related compounds. Its ability to undergo nucleophilic substitution reactions is particularly valuable for introducing the carbonyl chloride group into a variety of organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride is studied for its potential applications in the development of new drugs. Its unique structure and reactivity make it a candidate for targeting various biological pathways, which could lead to the creation of innovative treatments for different diseases.
It is crucial to handle Pyrazolo[1,5-a]pyrimidine-3-carbonyl chloride with care due to the high reactivity and corrosive nature of carbonyl chlorides, ensuring safety in both research and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 937602-40-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,7,6,0 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 937602-40:
(8*9)+(7*3)+(6*7)+(5*6)+(4*0)+(3*2)+(2*4)+(1*0)=179
179 % 10 = 9
So 937602-40-9 is a valid CAS Registry Number.
937602-40-9Relevant articles and documents
Efficient, Protecting Group Free Kilogram-Scale Synthesis of the JAK1 Inhibitor GDC-4379
Angelaud, Remy,Burkhard, Johannes,Gosselin, Francis,Lao, David,Marx, Andreas,Ochsenbein, Miriam,Ranjan, Rohit,Stumpf, Andreas,Xu, Di
, p. 2537 - 2550 (2021/11/24)
The development of an improved kilogram-scale synthesis of the JAK1 inhibitorGDC-4379for the treatment of asthma is described. The new process is highlighted by a step-economical construction of a 3-substituted-4-aminopyrazole employing a telescoped oximation and hydrazine condensation of a 1,3-dielectrophile to generate nitrosopyrazole and a novel copper-catalyzed NaBH4reduction of the nitroso group. The endgame process features an amidation of aminopyrazole with acid chloride under Schotten-Baumann conditions to provide access to the penultimate intermediate. A selective N-1 alkylation of the pyrazole moiety was accomplished under phase-transfer conditions, which deliveredGDC-4379with a defined particle-size distribution suitable for micronization after recrystallization and wet milling.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00617, (2021/08/13)
The present invention provides compounds, compositions thereof, and methods of using the same.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00920; 001553-001555, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
