937681-12-4 Usage
Description
2,2-DiMethylpiperidin-4-ol, also known as 2,2-Dimethyl-4-piperidinol, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which includes a piperidine ring with two methyl groups at the 2,2-position and a hydroxyl group at the 4-position. This structure endows it with specific chemical properties that make it valuable in the development of medications with targeted therapeutic effects.
Uses
Used in Pharmaceutical Industry:
2,2-DiMethylpiperidin-4-ol is used as a key intermediate in the synthesis of diphenylpyraline derivatives, which possess potent antimycobacterial activities. These derivatives are particularly effective against Mycobacterium tuberculosis, the causative agent of tuberculosis, a significant global health concern. 2,2-DiMethylpiperidin-4-ol's role in the development of new antimycobacterial drugs is crucial, as it contributes to the creation of more effective treatments for tuberculosis and potentially other mycobacterial infections.
Check Digit Verification of cas no
The CAS Registry Mumber 937681-12-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,7,6,8 and 1 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 937681-12:
(8*9)+(7*3)+(6*7)+(5*6)+(4*8)+(3*1)+(2*1)+(1*2)=204
204 % 10 = 4
So 937681-12-4 is a valid CAS Registry Number.
937681-12-4Relevant articles and documents
Antimycobacterial activity of diphenylpyraline derivatives
Weis, Robert,Faist, Johanna,di Vora, Ulrike,Schweiger, Klaus,Brandner, Barbara,Kungl, Andreas J.,Seebacher, Werner
, p. 872 - 879 (2008/09/21)
2-Substituted derivatives of diphenylpyraline and their 1-phenyl and 1-phenethyl analogues have been prepared in several steps from dihydropyridine-2(1H)-thiones. The structures of all new compounds have been confirmed by NMR spectroscopy. Their activity against Mycobacterium tuberculosis H37Rv as well as their cytotoxicity against human cells (HEK-293) have been determined via in vitro assays. The antimycobacterial potency was in general increased by substitution in ring position 2. The most promising modifications were a 2-isopropyl derivative and a 1,2-diphenyl analogue.
