937737-85-4Relevant articles and documents
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands
Caldwell, John P.,Matasi, Julius J.,Zhang, Hongtao,Fawzi, Ahmad,Tulshian, Deen B.
, p. 2281 - 2284 (2007)
A series of N-substituted analogs based upon the spiropiperidine core of 1 was synthesized and exhibited high binding affinity to the nociceptin (NOP) receptor. The selectivities against other known opioid receptors were determined.