93794-43-5

Basic information

• Product Name: 7-Methyl-benzooxazole-2-thiol
• Synonyms: 7-Methyl-benzooxazole-2-thiol
• CAS NO: 93794-43-5
• Molecular Formula: C8H7NOS
• Molecular Weight: 165.21228
• Mol File: 93794-43-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 266.4±33.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 11.17±0.20(Predicted)
• CAS DataBase Reference: 7-Methyl-benzooxazole-2-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Methyl-benzooxazole-2-thiol(93794-43-5)
• EPA Substance Registry System: 7-Methyl-benzooxazole-2-thiol(93794-43-5)

Safety Data

• Hazardous Substances Data: 93794-43-5(Hazardous Substances Data)

Upstream product

• 140-89-6 potassium ethyl xanthogenate 
• 17672-22-9 2-amino-6-methylphenol 
• 75-15-0 carbon disulfide 
• 13073-29-5 2-methyl-6-nitrophenol 
• 137-26-8 Thiram 
• 128-04-1 sodium dimethyldithiocarbamate 

Relevant articles and documents

AlCl3-Promoted Synthesis of 2-Mercapto Benzoheterocycles by Using Sodium Dimethyldithiocarbamate as Thiocarbonyl Surrogate

A simple, expeditious and high-efficiency synthetic method for the AlCl3-mediated one-pot preparation of 2-mercapto benzoheterocycles (2-mercapto benzothiazoles, benzoxazoles and benzimidazoles) is described. By the treatment of a series of S, O and N heteroatoms containing bifunctional molecules with sodium dimethyldithiocarbamate in AlCl3, the desired benzoheterocycles are obtained smoothly. The protocol can also be applied on the synthesis of a series of thiazolidine-2-thiones, imidazolidine-2-thiones. This novel synthetic approach has advantages such as ligand-free, high efficiency, short reaction time, readily available starting materials and simple experimental procedures.

Selective synthesis of 2-aminobenzoxazoles and 2-mercaptobenzoxazoles by using o-aminophenols as starting material

2-Aminobenzoxazoles and 2-mercaptobenzoxazoles were selectively synthesized by treating o-aminophenols with dithiocarbamates and tetramethylthiuram disulfide (TMTD), respectively. With the promotion of NaH/CuI, the reaction of o-aminophenols with dithioca

Serotonin 5-HT3 receptor partial activator

This invention provides a serotonin 5-HT3 receptor partial activator which has a serotonin 5-HT3 receptor activating action, in addition to its serotonin 5-HT3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT3 receptor antagonism and serotonin 5-HT3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT3 receptor partial activators. In the above formula, R1 to R4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R1 and R2 may be linked together to form a ring structure, namely benzene ring; R5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.