938184-95-3

Basic information

• Product Name: methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate
• Synonyms: methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate
• CAS NO: 938184-95-3
• Molecular Weight: 320.389
• Mol File: 938184-95-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate(938184-95-3)
• EPA Substance Registry System: methyl 3-(4-N-aminophenyl-4-carbomethoxy-piperidino)propionate(938184-95-3)

Safety Data

• Hazardous Substances Data: 938184-95-3(Hazardous Substances Data)

Upstream product

• 498-94-2 isonipecotic acid 
• 67-56-1 methanol 
• 1031691-16-3 methyl-3-(4-N-aminophenyl-4-carboxcylic acid-piperidino)proppionate 
• 404-24-0 2,2,2-trifluoro-N-phenylacetamide 
• 62-53-3 aniline 
• 75-18-3 dimethylsulfide 
• 124-41-4 sodium methylate 
• 292638-85-8 acrylic acid methyl ester 
• 74-88-4 methyl iodide 
• 149-73-5 trimethyl orthoformate 
• 61085-80-1 4-anilino-piperidine-4-carboxylic acid methyl ester 

Downstream Products

• 132539-07-2 remifnetanil hydrochloride 
• 132875-61-7 remifentanil 

Relevant articles and documents

Synthetic method of anesthetic analgesic drug

The invention discloses a synthetic method of an anesthetic analgesic drug. According to the synthetic method, 4-piperidinecarboxylic acid is used as a raw material and subjected to alkylation, bromination, methylation, acylation and the like to prepare the anesthetic analgesic drug. The method avoids the usage of highly toxic cyanide, so the safety and controllability of operation are improved; the method avoids an elimination reaction in reaction process, thereby accelerating reaction speed and shortening reaction time; and the method reduces reaction temperature, shortens the reaction time,and is more suitable for industrial production.

PROCESS FOR SYNTHESIZING REMIFENTANIL

A process for synthesizing remifentanil or carfentanil, as well as intermediates for use in the preparation of synthetic opiate or opioid compounds. The process comprising reacting a 4-amino 4-carbamyl piperidine with a base in a closed reaction chamber at elevated temperature and pressure to form to intermediate which may be esterified with an alcohol, alkylated, and acylated to produce a synthetic opiate or opioid compound.