93824-64-7Relevant articles and documents
A bridged azobenzene derivative as a reversible, light-induced chirality switch
Haberhauer, Gebhard,Kaliweit, Christine
, p. 2418 - 2421 (2010)
(Figure Presented) A new trick for an old dog: The azoben-zene derivative 1 was used to demon-strate the light-induced spatially directed (unidirectional) tran cis isomerization for the first time. This important effect expands the range of applications f
NOVEL BIS-CHROMONE DERIVATIVES, METHODS FOR THEIR PREPARATION AND USES THEREOF
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Page/Page column 21, (2014/07/08)
The invention relates to novel bis-chromone derivatives, methods for their preparation and their therapeutic application, especially in the treatment or prevention of disease involving mast cell activation, such as allergic disease. Provided is a compound according to the general Formula (I).
Design, synthesis, and inhibitory activity of potent, photoswitchable mast cell activation inhibitors
Velema, Willem A.,Van Der Toorn, Marco,Szymanski, Wiktor,Feringa, Ben L.
supporting information, p. 4456 - 4464 (2013/07/19)
Allergic reactions affect millions of people worldwide. The need for new and effective antiallergic agents is evident, and insight into the underlying mechanisms that lead to allergic events is necessary. Herein, we report the design, synthesis, and activity of photoswitchable mast cell activation inhibitors. In mast cell degranulation assays, these inhibitors possess significantly greater potency than an original, chromone-based antiallergic agent. Furthermore, one of the photoswitchable inhibitors shows a significant difference in inhibitory activity between its two photoisomeric forms. Further optimization could ultimately lead to a photoswitchable compound suitable for studying mechanisms involved in allergic reactions in a novel manner, with activity addressable by light and with precise spatiotemporal control over events at the molecular level.