93845-93-3Relevant articles and documents
Visible-light-mediated three-component Minisci reaction for heteroarylethyl alcohols synthesis
Dong, Jianyang,Liu, Jianhua,Liu, Yuxiu,Song, Hongjian,Wang, Qingmin,Yue, Fuyang
supporting information, p. 7963 - 7968 (2021/11/01)
Methods for heteroarylethyl alcohol synthesis are critical to the chemical and pharmaceutical industries. Herein, we report a mild, modular, practical Minisci reaction for catalytic synthesis of heteroarylethyl alcohols via sequential addition of H2O and N-heteroarenes across olefinic double bonds. This scalable protocol was used for direct hydroxy-heteroarylation of olefins with a wide range of N-heteroarenes and can be expected to permit rapid conversion of abundant feedstock materials into medically relevant molecules.
A NEW GENERAL METHOD OF HOMOLYTIC ALKYLATION OF PROTONATED HETEROAROMATIC BASES
Castaldi, Graziano,Minisci, Francesko,Tortelli, Vito,Vismara, Elena
, p. 3897 - 3900 (2007/10/02)
Alkyl iodides and benzoyl peroxides provide a new general method of homolytic alkylation of protonated heteroaromatic bases.Yields are good and the substitution is selective in the positions ortho and para to the heteroatom.
POLAR EFFECTS IN FREE-RADICAL REACTIONS. A NEW TYPE OF HOMOLYTIC AROMATIC ALKYLATION BY SILVER CATALYZED OXIDATION OF ACETONE BY PEROXYDISULPHATE IN THE PRESENCE OF OLEFINS.
Citterio, Attilio,Gentile, Anna,Minisci, Francesco
, p. 5587 - 5590 (2007/10/02)
Silver catalyzed peroxydisulphate oxidation of acetone in the presence of olefins and protonated heteroaromatic bases leads to compound I via addition of acetonyl radical to the olefin and scavenging of the resulting radical adduct by the aromatic base.