93865-76-0

Basic information

• Product Name: N-phenethyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine
• Synonyms: N-phenethyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine
• CAS NO: 93865-76-0
• Molecular Weight: 253.307
• Mol File: 93865-76-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-phenethyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenethyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine(93865-76-0)
• EPA Substance Registry System: N-phenethyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine(93865-76-0)

Safety Data

• Hazardous Substances Data: 93865-76-0(Hazardous Substances Data)

Upstream product

• 18591-70-3 8-Hydroxy-6-methyl-s-triazolo<4,3-b>pyridazin 
• 28593-25-1 8-chloro-6-methyl-s-triazolo<4,3-b>pyridazine 
• 64-04-0 phenethylamine 

Relevant articles and documents

Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors

Searching for selective tankyrases (TNKSs) inhibitors, a new small series of 6,8-disubstituted triazolo[4,3-b]piridazines has been synthesized and characterized biologically. Structure-based optimization of the starting hit compound NNL (3) prompted us to the discovery of 4-(2-(6-methyl-[1,2,4] triazolo[4,3-b]pyridazin-8-ylamino)ethyl)phenol (12), a low nanomolar selective TNKSs inhibitor working as NAD isostere as ascertained by crystallographic analysis. Preliminary biological data candidate this new class of derivatives as a powerful pharmacological tools in the unraveling of TNKS implications in physiopathological conditions.