93913-63-4Relevant articles and documents
New synthetic strategies towards (+)-artemisinin
Bhonsle, Jayendra B.,Pandey, Bipin,Deshpande, Vishnu H.,Ravindranathan
, p. 5489 - 5492 (1994)
Starting from (-)-menthol, two useful precursors for the formal total synthesis of (+)-Artemisinin, involving novel OH-assisted chemo and stereoselective C-H functionalisation and subsequent acid/base induced chemo-selective ring opening as key steps, have been synthesised.
TOTAL SYNTHESIS OF ARTEANNUIN AND DEOXYARTEANNUIN
Xu Xing-Xiang,Zhu Jie,Huang Da-Zhong,Zhou Wei-Shan
, p. 819 - 828 (2007/10/02)
Arteannuin 1 is a new sesquiterpene lactone containing a peroxide linkage and is an antimalarial principle isolated from Artemisia annua L. .R(+)-Citronellal 5 as a starting material for the total synthesis was converted into 11R(-)-methyl dihydroarteannuinate 12 in 14 steps.The key intermediate 4 was obtained from compound 12 in 5 steps.The introduction of hydroperoxide in 4 by photooxidation followed by acid treatment gave 1.Hydroxylation of 4 with osmium tetraoxide afforded deoxyarteannuin 2.