93943-65-8 Usage
Description
Phosphonium, (9-carboxynonyl)triphenyl-, bromide is a chemical compound that features a phosphonium cation with a 9-carboxynonyl group attached to a triphenyl moiety. Phosphonium, (9-carboxynonyl)triphenyl-, bromide is characterized by its ability to target mitochondria due to the presence of the mitochondria targeting motif (triphenylphosphonium). The bromide anion is associated with the phosphonium cation, resulting in a salt that can be utilized in various applications.
Uses
Used in Pharmaceutical Industry:
Phosphonium, (9-carboxynonyl)triphenyl-, bromide is used as a mitochondria-targeting agent for increasing the level of hydrogen sulphide within the mitochondria. This application is particularly relevant in the development of therapeutic agents aimed at modulating mitochondrial function and treating diseases associated with mitochondrial dysfunction.
Used in Research Applications:
In the field of scientific research, Phosphonium, (9-carboxynonyl)triphenyl-, bromide serves as a valuable tool for studying mitochondrial biology and the role of hydrogen sulphide in cellular processes. Researchers can utilize this compound to investigate the effects of elevated hydrogen sulphide levels on mitochondrial function and to explore potential therapeutic targets for various diseases.
Used in Drug Delivery Systems:
Phosphonium, (9-carboxynonyl)triphenyl-, bromide can be incorporated into drug delivery systems to enhance the targeting of therapeutic agents to mitochondria. This can improve the efficacy of drugs and reduce potential side effects by ensuring that the active compounds are delivered directly to the intended cellular compartment.
Check Digit Verification of cas no
The CAS Registry Mumber 93943-65-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,9,4 and 3 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 93943-65:
(7*9)+(6*3)+(5*9)+(4*4)+(3*3)+(2*6)+(1*5)=168
168 % 10 = 8
So 93943-65-8 is a valid CAS Registry Number.
93943-65-8Relevant articles and documents
TRIPHENYLPHOSPHONIUM-TETHERED TETRACYCYCLINES FOR USE IN TREATING CANCER
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Paragraph 00203, (2018/11/22)
This invention relates to compounds of formula (I) that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention al
The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39)
Le Trionnaire, Sophie,Perry, Alexis,Szczesny, Bartosz,Szabo, Csaba,Winyard, Paul G.,Whatmore, Jacqueline L.,Wood, Mark E.,Whiteman, Matthew
, p. 728 - 736 (2014/06/10)
Synthesis and bioavailability of the endogenous gasomediator hydrogen sulfide (H2S) is perturbed in many disease states, including those involving mitochondrial dysfunction. There is intense interest in developing pharmacological agents to generate H2S. We have synthesised a novel H2S donor molecule coupled to a mitochondria-targeting moiety (triphenylphosphonium; TPP+) and compared the effectiveness of the compound against a standard non-TPP+ containing H2S donor (GYY4137) in the inhibition of oxidative stress-induced endothelial cell death. Our study suggests mitochondria-targeted H2S donors are useful pharmacological tools to study the mitochondrial physiology of H2S in health and disease.
METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF
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Page/Page column 14, (2012/07/27)
Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.
