93953-13-0Relevant articles and documents
Barbier Continuous Flow Preparation and Reactions of Carbamoyllithiums for Nucleophilic Amidation
Ganiek, Maximilian A.,Becker, Matthias R.,Berionni, Guillaume,Zipse, Hendrik,Knochel, Paul
, p. 10280 - 10284 (2017)
An ambient temperature continuous flow method for nucleophilic amidation and thioamidation is described. Deprotonation of formamides by lithium diisopropylamine (LDA) affords carbamoyllithium intermediates that are quenched in situ with various electrophi