93968-89-9

Basic information

• Product Name: 2,2,5,5-tetramethyl-N-[1-(2,6-dimethylphenoxy)propan-2-yl]-2,5-dihydro-1H-pyrrole-3-carboxamide
• Synonyms: 2,2,5,5-tetramethyl-N-[1-(2,6-dimethylphenoxy)propan-2-yl]-2,5-dihydro-1H-pyrrole-3-carboxamide
• CAS NO: 93968-89-9
• Molecular Weight: 330.47
• Mol File: 93968-89-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,2,5,5-tetramethyl-N-[1-(2,6-dimethylphenoxy)propan-2-yl]-2,5-dihydro-1H-pyrrole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,5,5-tetramethyl-N-[1-(2,6-dimethylphenoxy)propan-2-yl]-2,5-dihydro-1H-pyrrole-3-carboxamide(93968-89-9)
• EPA Substance Registry System: 2,2,5,5-tetramethyl-N-[1-(2,6-dimethylphenoxy)propan-2-yl]-2,5-dihydro-1H-pyrrole-3-carboxamide(93968-89-9)

Safety Data

• Hazardous Substances Data: 93968-89-9(Hazardous Substances Data)

Upstream product

• 31828-71-4 RS-mexiletine 
• 19971-12-1 3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidine Hydrobromide 
• 5370-01-4 (rac)-mexiletine hydrochloride 
• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 

Downstream Products

• 102132-46-7 C₂₀H₃₁N₂O₃ 
• 93969-06-3 2,2,5,5-Tetramethyl-pyrrolidine-3-carboxylic acid [2-(2,6-dimethyl-phenoxy)-1-methyl-ethyl]-amide 
• 102132-42-3 C₂₀H₂₉N₂O₃ 

Relevant articles and documents

Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities

Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5-tetramethylpyrroline moiety, known for its antioxidant effect, in order to obtain dual-acting drugs potentially useful in the protection of the heart against post-ischemic reperfusion injury. The pyrroline derivatives reported herein were found to be more potent as antiarrhythmic agents than mexiletine and displayed antioxidant activity. The most interesting tetramethylpyrroline congener, a tert-butyl-substituted analogue, was at least 100 times more active as an antiarrhythmic than mexiletine.