93969-51-8

Basic information

• Product Name: 4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-(2-oxo-3-pyrrolidinyl)-2-phenyl-
• CAS NO: 93969-51-8
• Molecular Formula: C15H16N2O3
• Molecular Weight: 272.304
• Mol File: 93969-51-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-(2-oxo-3-pyrrolidinyl)-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-(2-oxo-3-pyrrolidinyl)-2-phenyl-(93969-51-8)
• EPA Substance Registry System: 4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-(2-oxo-3-pyrrolidinyl)-2-phenyl-(93969-51-8)

Safety Data

• Hazardous Substances Data: 93969-51-8(Hazardous Substances Data)

Upstream product

• 16673-80-6 6-methyl-2-phenyl-4H-1,3-oxazin-4-one 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 

Relevant articles and documents

1,3-Oxazines and Related Compounds. VIII. Reaction of 6-Methyl-2-phenyl-4H-1,3-oxazin-4-one with Lactams and Their Derivatives

6-Methyl-2-phenyl-4H-1,3-oxazin-4-one (1) underwent initial attack of the anions of lactams (2), such as ε-capro- (2a), δ-valero- (2b), and γ-butyro-lactams (2c), at the 4-position of the ring to give the corresponding α-substituted lactams (3a-c).Reaction of 1 with N-trimethylsilyl derivatives (6a-c) of 2 in the presence of lithium diisopropylamide afforded the 2,3-dihydro-4H-1,3-oxazin-4-one derivatives (7a-c), respectively.Similar treatment of 1 with O-methyl derivatives (9a-c) of 2 yielded the corresponding bicyclic heterocycles (10a-c).Keywords: 4H-1,3-oxazin-4-one; 2,3-dihydro-4H-1,3-oxazin-4-one; lithium diisopropylamide; butyllithium; ring transformation; lactam; lactim ether; N-trimethylsilyllactam.