939789-48-7

Basic information

• Product Name: 3-exo-(3-bromo-4-fluorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
• Synonyms: 3-exo-(3-bromo-4-fluorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester
• CAS NO: 939789-48-7
• Molecular Weight: 400.288
• Mol File: 939789-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-exo-(3-bromo-4-fluorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-exo-(3-bromo-4-fluorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester(939789-48-7)
• EPA Substance Registry System: 3-exo-(3-bromo-4-fluorophenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester(939789-48-7)

Safety Data

• Hazardous Substances Data: 939789-48-7(Hazardous Substances Data)

Upstream product

• 27407-11-0 3-bromo-4-fluorophenol 
• 143557-91-9 (1R,3S,5S)-tert-butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 

Relevant articles and documents

8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R1 is H or C1-5alkyl; Y is O, S or O(CH2)m; m is 1 or 2; n is 0 or 1; Ar1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar2, said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, phenyl, CN and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar2 to form a 5-membered ring; Ar2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, CN, CONR2R3, CO2R4, NHCOR5 and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar1 to form a 5-membered ring; R2-R4 are independently H or C1-5alkyl and R5 is C1-5alkyl, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising a 8- azabicyclo[3.2.1]octane derivative according to the present invention in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of a 8- azabicyclo[3.2.1]octane derivative according to the present invention in therapy.