94001-66-8

Basic information

• Product Name: Benzenemethanol, a-methyl-2-(phenylmethoxy)-
• Synonyms: 1-(2-Benzyloxy-phenyl)-ethanol;1-(2-Benzyloxy-phenyl)-aethanol;1-(2-benzyloxyphenyl)-ethanol;α-(o-Benzyloxy-phenyl)-aethylalkohol
• CAS NO: 94001-66-8
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• Mol File: 94001-66-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-methyl-2-(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-methyl-2-(phenylmethoxy)-(94001-66-8)
• EPA Substance Registry System: Benzenemethanol, a-methyl-2-(phenylmethoxy)-(94001-66-8)

Safety Data

• Hazardous Substances Data: 94001-66-8(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 98-86-2 acetophenone 
• 60632-93-1 1-Phenylethyl-diethylsilylether 
• 87804-23-7 2-(1-hydroxyethyl)phenol 
• 1257333-55-3 1,1-diethyl-3-methyl-1,3-dihydrobenzo[c][1,2]oxasilole 
• 100-44-7 benzyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 31165-67-0 2'-benzyloxyacetophenone 

Downstream Products

• 670274-84-7 4-[1-(2-benzyloxy-phenyl)-ethoxy]-3,5-dimethoxy-benzaldehyde 
• 134940-27-5 C₁₆H₁₅NO 
• 134940-28-6 2-(2-(benzyloxy)phenyl)propanoic acid 
• 134940-26-4 2-(2-(benzyloxy)phenyl)propanenitrile 
• 533931-68-9 2-hydroxyphenylpropanoic acid 
• 670274-86-9 4-{4-[1-(2-benzyloxy-phenyl)-ethoxy]-3,5-dimethoxy-benzyloxy}-benzaldehyde 
• 670274-82-5 3-{4-[1-(2-benzyloxy-phenyl)-ethoxy]-benzyloxy}-4-methoxy-benzaldehyde 
• 670274-85-8 {4-[1-(2-benzyloxy-phenyl)-ethoxy]-3,5-dimethoxy-phenyl}-methanol 
• 670274-81-4 {4-[1-(2-benzyloxy-phenyl)-ethoxy]-phenyl}-methanol 
• 627105-67-3 2-{2-[(E)-2-(2-Benzyloxy-phenyl)-propenyl]-phenyl}-2-methyl-[1,3]dioxolane 
• 627105-66-2 (+/-)-2-{2-[1-(2-benzyloxyphenyl)-ethanesulfonylmethyl]-phenyl}-2-methyl-[1,3]dioxolane 
• 627105-65-1 (+/-)-2-{2-[1-(2-benzyloxyphenyl)-ethylsulfanylmethyl]-phenyl}-2-methyl-[1,3]dioxolane 
• 627105-68-4 (+/-)-1-{2-[1-(2-benzyloxyphenyl)-ethanesulfonylmethyl]-phenyl}-ethanone 
• 627105-69-5 (+/-)-1-{2-[1-(2-benzyloxyphenyl)-ethanesulfonylmethyl]-phenyl}-ethanol 

Relevant articles and documents

Design, synthesis and biological evaluation of novel ring-opened cromakalim analogues with relaxant effects on vascular and respiratory smooth muscles and as stimulators of elastin synthesis

Two new series of ring-opened analogues of cromakalim bearing sulfonylurea moieties (series A: with N-unmethylated sulfonylureas, series B: with N-methylated sulfonylureas) were synthesized and tested as relaxants of vascular and respiratory smooth muscle

Synthesis of Ether Oligomers

(Equation presented) Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

Potential antitumor agents. 63. Structure-activity relationships for side-chain analogues of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid

A series of 16 analogues of the solid tumor active compound 9-oxo-9H-xanthene-4-acetic acid (XAA), with variations in the acetic acid side chain, have been prepared and evaluated for their ability to cause early haemorrhagic necrosis of colon 38 tumors in mice. The results extend the previous SAR for this class and confirm the necessity for a carboxylic acid group in a fixed disposition with respect to the xanthenone chromophore. None of the compounds showed superior potency to XAA itself, with virtually all alterations in the nature of the anionic center or its geometry with respect to the chromophore greatly reducing or abolishing activity. However, α-methylation of the side chain was permissible, and the two enantiomers of 5-methyl-α-methyl-XAA were separated and tested. Both were active, but the S-(+) enantiomer was much more dose-potent than the R-(-) enantiomer, in both the in vivo tumor necrosis assay and an in vitro assay measuring the stimulation of nitric oxide production by macrophages. This suggests that the enantiomers have different intrinsic activities, rather than differing in their vivo metabolism.