94088-74-1

Basic information

• Product Name: 3',5'-dimethoxybenzanilide
• Synonyms: 3',5'-dimethoxybenzanilide;N-(3,5-Dimethoxyphenyl)benzamide
• CAS NO: 94088-74-1
• Molecular Formula: C₁₅H₁₅NO₃
• Molecular Weight: 257.2845
• EINECS: 302-076-3
• Mol File: 94088-74-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 326.8°Cat760mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.189g/cm³
• CAS DataBase Reference: 3',5'-dimethoxybenzanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 3',5'-dimethoxybenzanilide(94088-74-1)
• EPA Substance Registry System: 3',5'-dimethoxybenzanilide(94088-74-1)

Safety Data

• Hazardous Substances Data: 94088-74-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 10272-07-8 3.5-dimethoxyaniline 
• 380501-39-3 N-(2-acetyl-3,5-dimethoxy-phenyl)-benzamide 
• 583-04-0 vinyl benzoate 
• 65-85-0 benzoic acid 
• 17213-58-0 3,5-dimethoxybenzamide 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 100-47-0 benzonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 305834-42-8 N-(3,5-dimethoxy-2-methoxyacetyl-phenyl)-benzamide 
• 380501-39-3 N-(2-acetyl-3,5-dimethoxy-phenyl)-benzamide 
• 159188-33-7 5,7-dimethoxy-2-phenylquinoline-4(1H)-one 
• 380501-40-6 5-hydroxy-7-methoxy-2-phenyl-4-quinolone 
• 305834-49-5 3,5,7-trimethoxy-2-phenyl-1H-quinolin-4-one 
• 1156271-96-3 4-chloro-5,7-dimethoxy-2-phenylquinoline 
• 1346015-66-4 5,7-dimethoxy-2-phenyl-N-propylquinoline-4-amine 
• 1346015-58-4 N-butyl-5,7-dimethoxy-2-phenylquinoline-4-amine 

Relevant articles and documents

Design, synthesis, and antitubercular activity of 3-amidophenols with 5-heteroatomic substitutions

A series of novel 3-amidophenols with 5-heteroatomic substitutions were designed and synthesized. Several compounds showed potent antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC = 0.25–5 μg/mL). Compounds 12j and 14i also displayed good inhibitory activity against M. tuberculosis H37Rv and two clinically isolated multidrug-resistant M. tuberculosis strains (MIC = 0.39–3.12 μg/mL). The privileged compound 14i showed certain oral efficacy on a mouse infection model. The compounds are non-cytotoxic against L-O2 hepatocytes and RAW264.7 macrophagocytes. They did not exert inhibitory activity against representative Gram-positive and Gram-negative bacteria.

Triflic anhydride mediated synthesis of 3,4-dihydroquinazolines: A three-component one-pot tandem procedure

A one-pot three-component tandem reaction involving a key Pictet-Spengler-like annulation step has been developed, providing an efficient method for the synthesis of 3,4-dihydroquinazolines in moderate to good yields from amides, aldehydes, and amines. The multicomponent triflic anhydride mediated reaction tolerates the installation of numerous functional groups, affording extensive diversity about the heterocyclic scaffold.

Synthesis and antitumor activity of novel 4-aminoquinoline derivatives

A series of novel 4-aminoquinoline derivatives were synthesized as antitumor agents by reacting 4-chloroquinoline with the corresponding mono/dialkyl amines. The cytotoxicity of these compounds was evaluated in vitro against HCT-116, A549, DU-145, HepG2, and LN229 cell lines. The results showed that most of the synthesized compounds displayed excellent cytotoxicity, and 5,7-dimethoxy-2-phenyl-N-propylquinoline-4-amine (6a) displayed the most potent cytotoxicity against HCT-116 cells. Furthermore, 6a could decrease VEGF protein expression.