941685-08-1Relevant articles and documents
PYRIDO-OXAZINE DERIVATIVES AS ALK5 INHIBITORS
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Page/Page column 76-77, (2022/01/24)
The present invention relates to a compound of general formula (I) inhibiting the growth factor receptor transforming β (TGF-β) type I (ALK5), methods for preparing such compounds, pharmaceutical compositions containing them and their therapeutic use. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the ALK5 signaling pathway in a mammal.
COLLAGEN 1 TRANSLATION INHIBITORS AND METHODS OF USE THEREOF
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Paragraph 0070-0071, (2021/10/30)
The present invention relates to novel Collagen 1 translation inhibitors, composition and methods of preparation thereof, and uses thereof for treating Fibrosis including lung, liver, kidney, cardiac and dermal fibrosis, IPF, wound healing, scarring and Gingival fibromatosis, Systemic Sclerosis, and alcoholic and non-alcoholic steatohepatitis (NASH).
TYROSINE ANALOGUES DERIVATIVES AS RHO- KINASE INHIBITORS
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Page/Page column 56, (2019/04/09)
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).