94189-81-8

Basic information

• Product Name: Thymidine, 3-benzoyl-, 3'-benzoate
• CAS NO: 94189-81-8
• Molecular Formula: C24H22N2O7
• Molecular Weight: 450.448
• Mol File: 94189-81-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Thymidine, 3-benzoyl-, 3'-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 3-benzoyl-, 3'-benzoate(94189-81-8)
• EPA Substance Registry System: Thymidine, 3-benzoyl-, 3'-benzoate(94189-81-8)

Safety Data

• Hazardous Substances Data: 94189-81-8(Hazardous Substances Data)

Upstream product

• 50-89-5 thymidine 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 
• 741687-35-4 di-N-3,O-3'-benzoyl-5'-O-tert-butyldimethylsilylthymidine 

Downstream Products

• 1069059-94-4 C₄₀H₃₉N₂O₁₁P 
• 124130-15-0 N³,3',5'-O-tribenzoyl thymidine 
• 1259874-63-9 C₂₉H₃₁N₂O₁₂P 
• 1357487-07-0 N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine 
• 1357487-08-1 N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(benzyloxycarbonyl)phosphonomethyl]thymidine 
• 119484-04-7 C₆₅H₅₉N₈O₁₅P 
• 138612-61-0 C₅₅H₅₂N₄O₁₄ 
• 138560-40-4 Benzoic acid (2R,3S,5R)-5-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yloxymethoxymethyl]-tetrahydro-furan-3-yl ester 
• 741687-36-5 di-N-3,O-3'-benzoyl-5'-O-allylthymidine 

Relevant articles and documents

Design and synthesis of α-carboxy phosphononucleosides

Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.

One step selective 5′-O-allylation of thymidine using microwave or ultrasound activation

An improved procedures for the synthesis of 5′-O-allylthymidine via one step selective allylation of thymidine using either ultrasound or microwave activation is described.