942199-56-6

Basic information

• Product Name: 2-chloro-5-cyanobenzene-1-sulfonyl chloride
• Synonyms: 2-chloro-5-cyanobenzene-1-sulfonyl chloride;2-chloro-5-cyanobenzenesulfonyl chloride;Benzenesulfonyl chloride, 2-chloro-5-cyano-
• CAS NO: 942199-56-6
• Molecular Formula: C₇H₃Cl₂NO₂S
• Molecular Weight: 236.07522
• Mol File: 942199-56-6.mol
• Article Data: 3

Chemical Properties

• Appearance: powder
• Density: 1.65
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-chloro-5-cyanobenzene-1-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-5-cyanobenzene-1-sulfonyl chloride(942199-56-6)
• EPA Substance Registry System: 2-chloro-5-cyanobenzene-1-sulfonyl chloride(942199-56-6)

Safety Data

• Hazardous Substances Data: 942199-56-6(Hazardous Substances Data)

Usage

General Description

2-chloro-5-cyanobenzene-1-sulfonyl chloride, also known as 2-chloro-5-cyanobenzene-1-sulfonyl chloride, is a chemical compound with the molecular formula C7H4ClNO2S. It is a sulfonyl chloride derivative with a chlorine atom and a cyano group attached to the benzene ring. 2-chloro-5-cyanobenzene-1-sulfonyl chloride is used in organic synthesis as a versatile building block for the preparation of various pharmaceuticals and agrochemicals. It is also used as a reagent for the introduction of the sulfonyl chloride functional group into organic molecules, and as a precursor for the synthesis of other functionalized benzene derivatives. Additionally, it can be used as a cross-linking agent in polymer chemistry and as a reagent in the synthesis of dyes and pigments. Overall, 2-chloro-5-cyanobenzene-1-sulfonyl chloride has broad applications in organic chemistry and is an important intermediate in the production of various valuable compounds.

InChI:InChI=1S/C7H3Cl2NO2S/c8-6-2-1-5(4-10)3-7(6)13(9,11)12/h1-3H

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 939-80-0 4-chloro-3-nitrobenzonitrile 
• 53312-79-1 3-amino-4-chloro-benzonitrile 

Downstream Products

• 1067904-09-9 C₁₈H₁₉ClN₂O₂S 
• 1334523-89-5 C₁₇H₂₂ClN₃O₄S 
• 1334523-34-0 N-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-fluorobenzenesulfonamide 
• 1334523-88-4 3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile 
• 1334523-35-1 1-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-(3-fluorophenyl)urea 
• 1334523-64-6 1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea 
• 1334523-87-3 C₂₃H₂₅Cl₂N₃O₅S 
• 1939-76-0 4-chloro-3-sulfamoylbenzonitrile 

Relevant articles and documents

Research on controllable degradation of sulfonylurea herbicides

In order to seek ecologically safer and environmentally benign sulfonylurea herbicides (SU), insight into the structure/bioassay/soil degradation tri-factor relationship was first established. With the introduction of various groups (alkyl, nitro, halogen, cyano etc.) at the 5th position of its benzene ring, structural derivatives of chlorsulfuron were designed, synthesized, and evaluated for their herbicidal activity. The structures of the title compounds were confirmed by infrared spectroscopy, ultraviolet spectroscopy, 1H and 13C NMR, mass spectrometry, elemental analysis and X-ray diffraction. Bioassay results confirmed that most derivatives retained their superior herbicidal activities in comparison with chlorsulfuron. After investigating the soil degradation behavior of each molecule under set conditions, it was found that structures with electron-withdrawing substituents at the 5th position of the benzene ring retained their long degradation half-lives, yet the introduction of electron-donating substituents accelerated the degradation rate. These results will provide a valuable clue to further explore the potential controllable degradation of SU and other herbicides, and to discover novel herbicides that are favorable for environmentally and ecologically sustainable development.

ORGANIC COMPOUNDS

There are provided according to the invention compounds of formula (I), in free or salt form, wherein R1, R2, R3, R4, R5, R6, Q, W, X, m, n and p are as described in the specification, process for preparing them, and their use as pharmaceuticals.