94220-45-8 Usage
Description
5-Chloro-1H-pyrazolo[4,3-b]pyridine is a chemical compound that serves as an intermediate in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes a pyrazolo[4,3-b]pyridine core with a chloro substituent at the 5-position. 5-Chloro-1H-pyrazolo[4,3-b]pyridine plays a crucial role in the development of therapeutic agents targeting specific biological pathways.
Uses
Used in Pharmaceutical Industry:
5-Chloro-1H-pyrazolo[4,3-b]pyridine is used as a key intermediate in the synthesis of 2-aryl or heteroaryl indole derivatives. These derivatives act as ASIC (acid-sensing ion channel) modulators, which have potential applications in treating pain, bone diseases, and other disorders. By modulating the activity of ASIC channels, these indole derivatives can help regulate the body's response to acidic conditions, providing relief from pain and other symptoms associated with various conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 94220-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,2,2 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 94220-45:
(7*9)+(6*4)+(5*2)+(4*2)+(3*0)+(2*4)+(1*5)=118
118 % 10 = 8
So 94220-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClN3/c7-6-2-1-4-5(9-6)3-8-10-4/h1-3H,(H,8,10)
94220-45-8Relevant articles and documents
Neurotrophic factor tyrosine kinase receptor inhibitor
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Paragraph 0745; 0747-0749, (2018/05/30)
The invention provides a neurotrophic factor tyrosine kinase receptor inhibitor. The tyrosine kinase receptor inhibitor provided by the invention has a tricyclic parent core structure, can inhibit theactivity of Trk kinase and can be used for treating mammalian diseases mediated by the Trk kinase.