942857-22-9

Basic information

• Product Name: 3,8-bis(4-methylphenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile
• CAS NO: 942857-22-9
• Molecular Weight: 374.466
• Mol File: 942857-22-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,8-bis(4-methylphenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3,8-bis(4-methylphenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile(942857-22-9)
• EPA Substance Registry System: 3,8-bis(4-methylphenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile(942857-22-9)

Safety Data

• Hazardous Substances Data: 942857-22-9(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 106-49-0 p-toluidine 
• 70638-53-8 4‐oxo‐2‐thioxo‐6‐(p-tolyl)‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile 

Downstream Products

• 70638-53-8 4‐oxo‐2‐thioxo‐6‐(p-tolyl)‐1,2,3,4‐tetrahydropyrimidine‐5‐carbonitrile 

Relevant articles and documents

The Mannich reaction in the synthesis of N,S-containing heterocycles : 55*5. Synthesis and structures of new pyrimido[2,1-b][1,3,5] thiadiazine derivatives

Reactions of 6-aryl-5-cyano-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidines with formaldehyde and primary amines gave earlier unknown 3,4-dihydro-2H,6H- pyrimido[2,1-b]-[1,3,5]thiadiazine derivatives in 58-94% yields. In boiling AcOH, these pyrimidothiadiazines underwent the retro-Mannich reaction leading to the starting pyrimidine-2-thiones. The structure of 3-(4-ethoxyphenyl)-6-oxo-8- phenyl-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazine-7-carbonitrile was studied by X-ray diffraction analysis.