943117-82-6

Basic information

• Product Name: 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile
• Synonyms: 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile
• CAS NO: 943117-82-6
• Molecular Weight: 246.671
• Mol File: 943117-82-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile(943117-82-6)
• EPA Substance Registry System: 2-chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile(943117-82-6)

Safety Data

• Hazardous Substances Data: 943117-82-6(Hazardous Substances Data)

Upstream product

• 1765-93-1 4-fluoroboronic acid 
• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 

Downstream Products

• 1428522-37-5 6-(4-fluorophenyl)-2-((4-isopropylphenyl) amino)-4-methylnicotinonitrile 
• 1428522-38-6 C₂₁H₁₈FN₃ 
• 1428522-39-7 C₂₀H₁₆FN₃ 
• 1428522-40-0 C₂₀H₁₆FN₃O 
• 1428522-41-1 C₂₁H₁₈FN₃O₂ 
• 1428522-42-2 C₁₉H₁₄FN₃ 
• 1428522-43-3 C₁₉H₁₃F₂N₃ 
• 1428522-44-4 C₂₀H₁₆FN₃S 
• 1428522-45-5 C₁₉H₁₃ClFN₃ 
• 1428522-46-6 C₁₉H₁₃ClFN₃ 
• 1428522-47-7 C₂₁H₁₈FN₃O₂ 
• 1428522-48-8 C₁₉H₁₃BrFN₃ 
• 1428522-49-9 C₂₂H₂₀FN₃O₃ 

Relevant articles and documents

A facile synthesis of tetracyclic benzo-pyridonaphthyridines by domino reaction

A novel methodology for the synthesis of tetracyclic benzo- pyridonaphthyridines, forming a C-C and a C-N bond in concentrated sulfuric acid at 70 °C in a one-pot is reported. The key substrates (9a-m) are prepared by reacting 2-chloro-6-(4-fluorophenyl)-4-methylnicotinenitrile (7) with various anilines followed by dimethylformamide dimethylacetal. The domino reaction is initiated by the protonation of the b-carbon of the enamine group in 9a-m and terminated by the elimination of dimethylamine.