943153-22-8

Basic information

• Product Name: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID
• Synonyms: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID;5-CHLORO-2-METHOXY-PYRIDINE-3-BORONIC ACID;5-chloro-2-Methoxypyridin-3-yl-3-boronic acid
• CAS NO: 943153-22-8
• Molecular Formula: C₆H₇BClNO₃
• Molecular Weight: 187.39
• Product Categories: Boronic Acid;pyridine series
• Mol File: 943153-22-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 148-152°C
• Boiling Point: 353.1 °C at 760 mmHg
• Flash Point: 167.3 °C
• Appearance: /
• Density: 1.4 g/cm³
• Refractive Index: 1.545
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.93±0.58(Predicted)
• CAS DataBase Reference: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID(943153-22-8)
• EPA Substance Registry System: (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID(943153-22-8)

Safety Data

• Hazardous Substances Data: 943153-22-8(Hazardous Substances Data)

Usage

Description

(5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID is a white solid chemical compound that serves as a valuable research chemical. It is primarily utilized in the synthesis of triazine derivatives, which are known to act as phosphodiesterase inhibitors. These derivatives have potential applications in the treatment of various central nervous system (CNS) disorders, metabolic disorders, and other diseases.

Uses

Used in Pharmaceutical Industry:
(5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID is used as a key intermediate in the synthesis of triazine derivatives for the development of phosphodiesterase inhibitors. These inhibitors are crucial for treating CNS disorders, metabolic disorders, and other diseases, as they help regulate the levels of cyclic nucleotides, which play a significant role in various physiological processes.
Used in Research and Development:
In the field of research and development, (5-CHLORO-2-METHOXYPYRIDIN-3-YL)BORONIC ACID is employed as a versatile building block for the creation of novel compounds with potential therapeutic applications. Its unique structure allows for the exploration of new chemical pathways and the discovery of innovative treatments for a wide range of medical conditions.

InChI:InChI=1/C6H7BClNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3,10-11H,1H3

Downstream Products

• 943153-26-2 (R)-1-[4-(5-chloro-2-methoxypyridin-3-yl)-phenyl]-ethylamine 
• 943153-34-2 [4-(5-chloro-2-methoxy-pyridin-3-yl)-3-methoxy-benzyl]-carbamic acid tert-butyl ester 
• 943153-23-9 [4-(5-chloro-2-methoxypyridin-3-yl)-3-trifluoromethoxy-benzyl]-carbamic acid-tert-butyl ester 

Relevant articles and documents

IMIDAZO [1,2-B] PYRIDAZINE AND IMIDAZO [4,5-B] PYRIDINE DERIVATIVES AS JAK INHIBITORS

New imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).