94333-62-7

Basic information

• Product Name: 3-AMINO-3-(THIOPHEN-3-YL)PROPANOIC ACID
• Synonyms: 3-AMINO-3-(THIOPHEN-3-YL)PROPANOIC ACID
• CAS NO: 94333-62-7
• Molecular Formula: C₇H₉NO₂S
• Molecular Weight: 171.22
• EINECS: 305-042-6
• Mol File: 94333-62-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 208-210°
• Boiling Point: 332.7 °C at 760 mmHg
• Flash Point: 155 °C
• Appearance: /
• Density: 1.345g/cm³
• PKA: 3.48±0.12(Predicted)
• CAS DataBase Reference: 3-AMINO-3-(THIOPHEN-3-YL)PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-3-(THIOPHEN-3-YL)PROPANOIC ACID(94333-62-7)
• EPA Substance Registry System: 3-AMINO-3-(THIOPHEN-3-YL)PROPANOIC ACID(94333-62-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 94333-62-7(Hazardous Substances Data)

Usage

General Description

3-Amino-3-(thiophen-3-yl)propanoic acid, also known as ATPA, is a chemical compound with the molecular formula C8H10NO2S. It is an amino acid derivative with a thiophene ring attached to the carbon chain. ATPA is a potent and selective agonist for the glutamate receptor subtypes and has been used in research to study the role of these receptors in various physiological and pathological processes. It has also been investigated for its potential therapeutic applications in the treatment of neurological disorders. ATPA has shown promise as a tool compound for studying glutamate receptors and may have future applications in drug development for conditions such as Alzheimer's disease, Parkinson's disease, and epilepsy.

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 141-82-2 malonic acid 
• 631-61-8 ammonium acetate 

Downstream Products

• 108046-09-9 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-thiophen-3-yl-propionic acid 
• 108046-16-8 4-Amino-4,5-dihydro-cyclopenta[b]thiophen-6-one; hydrochloride 
• 108046-13-5 N-(6-Hydroxy-5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)-2-hydroxymethyl-benzamide 
• 108046-24-8 5,6-dihydro-4H-cyclopenta[b]thiophen-4-ylamine 

Relevant articles and documents

PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

Burkholderia cepacia lipase is an excellent enzyme for the enantioselective hydrolysis of β-heteroaryl-β-amino esters

The enantioselective (E >200) lipase PS-catalysed hydrolysis of β-heteroaryl-β-amino esters is described. The reactions were performed with H2O (0.5 equiv) in either diisopropyl ether or tert-butyl methyl ether at 25 °C. The resulting β-heteroaryl-substituted β-amino acid enantiomers were formed in high enantiomeric excess (ee ≥ 97%) and in good yield (≥40%).

A convenient synthesis of dihydro- and tetrahydro-1,3-thiazine derivatives from β-aryl-β-amino acids

A facile synthesis of 2-alkyl-4-aryl-5,6-dihydro-4H-1,3-thiazines and cis-2-alkyl-4-aryl-3,4,5,6-tetrahydro-2H-1,3-thiazines with potential therapeutic interest was achieved starting from readily accessible β-aryl-β-amino acids.